Lineage trajectories differ by mutation
نویسندگان
چکیده
منابع مشابه
Defining Developmental Potency and Cell Lineage Trajectories by Expression Profiling of Differentiating Mouse Embryonic Stem Cells
Biologists rely on morphology, function and specific markers to define the differentiation status of cells. Transcript profiling has expanded the repertoire of these markers by providing the snapshot of cellular status that reflects the activity of all genes. However, such data have been used only to assess relative similarities and differences of these cells. Here we show that principal compon...
متن کاملRobustness of coalescent estimators to between-lineage mutation rate variation.
Data from HIV and from human neoplastic cells can show substantial between-lineage mutation rate variation even within a single population. Such variation may affect estimators of population quantities such as Theta = 4N(e)mu. Using simulated DNA data, I measured the effect of rate variation on recovery of Theta by the summary-statistic estimator of Watterson (Watterson GA. 1975. On the number ...
متن کاملConstructing Maps by Clustering Trajectories
We propose a new approach for constructing the underlying map from trajectory data. This algorithm is based on the idea that road segments can be identified as stable subtrajectory clusters in the data. For this, we consider how subtrajectory clusters evolve for varying distance values, and choose stable values for these, in this way avoiding a global proximity parameter. Within trajectory clus...
متن کاملSmoothing speech trajectories by regularization
The articulators of human speech might only be able to move slowly, which results in the gradual and continuous change of acoustic speech properties. Nevertheless, the so-called speech continuity is rarely explored to discriminate different phones. To exploit this, this paper investigates a multiple-frame MFCC representation (that is expected to retain sufficient time-continuity information) in...
متن کاملACL Reconstruction: Do Outcomes Differ by Sex?
Background: Anterior cruciate ligament (ACL) reconstruction is frequently performed to restore knee stability and function following ACL injury. Female sex is known to predispose to ACL injury; however, it remains unclear whether female sex predisposes to poor outcomes following ACL reconstruction. We hypothesized that male and female patients exhibit no differences in (1) graft failure risk, (...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2021
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.371.6529.581-g